Research Team
CO-PRINICIPAL INVESTIGATORS
Rima Kaddurah-Daouk
Duke University
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Professor in the Departments of Psychiatry and Medicine at Duke University Medical Center. A pioneer in the metabolomics field. She successfully led 5 NIH-funded consortia related to applications of metabolomics in precision medicine including MDPMC, Accelerating Medicines Partnership-AD, Alzheimer Gut Microbiome Initiative; cofounded Metabolomics Society, and Metabolon, a leading biotechnology company specializing in metabolomics. She has extensive experience in assembling teams of researchers to work collaboratively on large scientific projects and has secured over 40 NIH-funded grants over the past decade.
Rob Knight
UC San Diego
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Professor at the University of California San Diego. He is co-founder of the American Gut Project and the Earth Microbiome Project specializing in the development of computational and lab techniques to define human, animal, and environmental microbes.
Sarkis Mazmanian
CalTech
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Professor of Microbiology at the California Institute of Technology. He is a medical microbiologist whose research focuses on the gut-brain axis of communication. His lab was the first to demonstrate that intestinal bacteria direct universal development of the immune system, and control complex behaviors in preclinical models.
Management Team
Edgar Diaz
Duke University
Leyla Schimmel
Duke University
Investigators
Gabi Kastenmüller
Helmholtz Zentrum München
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Acting director of the Institute of Bioinformatics and Systems Biology. Her focus is on human chemical individuality and its effects in health, disease, and treatment, metabolome and genome associations, and bioinformatic tools and databases for metabolomics data analysis.
Matthias Arnold
Helmholtz Zentrum München
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Adjunct Assistant Professor at Duke University. Bioinformatician and lead analyst on metabolomics projects at the Helmholtz Zentrum München. Specializes in metabolomics data and its integration with multi-omics into networks.
Jan Krumsiek
Weill Cornell Medicine
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Assistant Professor of Physiology and Biophysics and Computational Genomics. He develops and applies new analytical methods, including machine learning and bioinformatics, to metabolomics and multi-omic data analysis.
Ines Thiele
NUI Galway
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PI of the Molecular Systems Physiology group. She pioneered models and methods allowing large scale computational modelling of the human gut microbiome and its metabolic effect on human metabolism. Her research aims to improve the understanding of how diet influences human health.
Thomas Hankemeier
Leiden University
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Professor of Analytical BioSciences at the LACDR, PI of the Analytical BioSciences and Metabolomics group, and the Division of Systems Biomedicine and Pharmacology Chair. His research involves innovative analytical tools for metabolomics driven systems biology in personalized health.
Pieter Dorrestein
UC San Diego
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Professor of Pharmacy and Pharmaceutical Sciences, Director of the Collaborative Mass Spectrometry Innovation Center, and Co-Director of the Institute for Metabolomics Medicine. His lab is developing new mass spectrometry-based methods to explore the chemistry of microbes and the human microbiome.
Peter Miekle
Baker Heart & Diabetes Institute
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Professor and Head of Metabolomics Lab at Baker Heart & Diabetes Institute. His research uses state-of-the-art tandem mass spectrometry to obtain lipidomic profiles to provide improved diagnostic and therapeutic approaches for a range of metabolic diseases.
Oliver Fiehn
UC Davis
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Director, West Coast Metabolomics Center. Pioneered developments and applications in metabolomics
David Wishart
University of Alberta
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Distinguished Professor and Director of TMIC, led the Human Metabolome Project (HMP), created the MiMeDB (Microbial Metabolites Database), and FooDB (characterizing chemical consitutents of various foods and food-associated biomarkers).
Matej Oresic
Örebro University
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Professor of Medicine, Expertise in exposomics and metabolomics applications in biomedical research
Tuulia Hyötyläinen
Örebro University
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Professor of Chemistry, Dr. Hyötyläinen’s lab develops efficient, high-throughput methodologies for profiling of the biological samples. Her recent work has expanded to cover previously unreported bile acids.
Emeran Mayer
UCLA
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Professor of Medicine, Physiology, and Psychiatry. Director of the G. Oppenheimer Center for Neurobiology of Stress and Resilience. He is recognized as a leading investigator of brain gut microbiome interactions in GI disorders, including functional and inflammatory bowel disorders and obesity.
Andy Saykin
Indiana University
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Professor of Radiology; Director of the Indiana ADRC and the Center for Neuroimaging. He uses brain imaging and genomic methods to study mechanisms of memory dysfunction and treatment response in neurological and psychiatric disorders.
Kwangsik Nho
Indiana University
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Associate Professor of Radiology & Imaging Sciences. His research expertise is in the areas of bioinformatics, imaging informatics, and medical informatics. He integrates omics data to perform next generation sequence analysis to gain deeper understanding of the pathogenesis of complex diseases.
Jared Brosch
Indiana University
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Associate Professor of Neurology. Dr. Brosch is a Neurologist and Faculty of the Indiana Alzheimer Disease Research Center. He helps coordinate activities across AGMP-affiliated ADRCs.
Murali Doraiswamy
Duke University
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Professor of Medicine & Psychiatry & Behavioral Sciences; Director of the Neurocognitive Disorders Program and a clinical trials unit involved in the development of many modern diagnostic tests, apps, algorithms, and therapeutics.
Ali Keshavarzian
Rush University
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Professor, Departments of Internal Medicine, Pharmacology, and Molecular Physiology. Director of the Rush Center for Microbiome and Chronobiology Research and the Institute for Advanced Study of the Gut, Chronobiology & Inflammation. He studies the impact of environmental factors on intestinal barrier function host/microbe interaction that promote intestinal and systemic (gut-derived) inflammation.
Robin Voigt-Zuwala
Rush University
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Associate Professor, Department of Internal Medicine. Director of Operations of the Rush Center for Microbiome and Chronobiology Research. She studies the microbiota-gut-brain axis in Alzheimer’s disease, Parkinson’s disease, and post-traumatic stress disorder.
Laura Baker
Wake Forest University
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Professor of Gerontology and Geriatric Medicine; Dr. Baker is lead co-PI of U.S. POINTER, a landmark AD prevention trial, co-chair of the ACTC Non-Pharmacological Interventions Committee, and leads the Inclusion/Diversity Committee of the Recruitment Unit. Her research focuses on Alzheimer’s prevention.
Suzanne Craft
Wake Forest University
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Professor of Gerontology and Geriatric Medicine. Dr. Craft’s research has centered around Alzheimer’s disease, cognitive disorders, dementia, diet, and insulin resistance. She leads the Wake Forest AD Research Center and the BEAT-AD clinical diet trial which examines the effects of a modified Mediterranean-Ketogenic Diet on AD biomarkers and cognition.
Tatiana Foroud
NCRAD
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Professor of Medical and Molecular Genetics where she chairs the department at Indiana University. She is also a geneticist and leader in dementia research, and the head of the National Centralized Repository for Alzheimer’s Disease and Related Dementias (NCRAD), the NIH funded National Repository for Alzheimer’s Disease and Related Dementias.
Anna Greenwood
Sage Bionetworks
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Director Alzheimer’s Disease Translational Research. Her work focuses on advancing neuroscience research using team-based, open scientific approaches. Her current projects are aimed at building tools and processes to enable the Alzheimer’s disease research community to access and interpret open data and resources
Cornelia van Duijn
Oxford University
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Professor of Epidemiology at Nuffield Department of Population Health and a Fellow of St Cross College, Oxford.Her research at the Oxford Big Data Institute focuses on large scale omics studies of Alzheimer’s Disease and other neurodegenerative disorders.
Arfan Ikram
Erasmus Medical Centre
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Professor of Epidemiology. Dr. Ikram is the PI of the Rotterdam study and his research seeks to elucidate the earliest signs of brain diseases, before clinical symptoms are present, and to understand how these lead to clinical manifestation of disease